The objective of the Prince of Wales Medical Research Institute Brain Bank is to provide a research resource facility for the collection, characterisation, storage and distribution of human brain tissue for research purposes. Our primary focus is on various neurodegenerative conditions and also unaffected people. Neurodegenerative disorders have a huge personal impact in addition to being an increasing economic burden to individuals and the community. There are currently no treatments for many of these disorders, and only symptomatic treatment for some. Researchers in Australia and overseas interested in investigating areas such as basic disease mechanisms, earlier and more accurate diagnosis, genetic contributions to diseases, better treatments, and ultimately, cure and prevention, can request this tissue for their research studies. To be successful in our goals, we rely on the generosity and altruism of people who donate their brains for research and also the scientists who request the tissue seeking to alleviate the suffering that neurodegenerative diseases cause.